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Selected Pharmaceuticals in Development as of October 18, 2022

Cardiovascular and Metabolism

XARELTO (rivaroxaban)

COVID-19 MI (PREVENT-HD)
Phase 3

AAV-RPGR

Retinitis Pigmentosa
Phase 3

aprocitentan

Difficult to treat hypertension
Phase 3

AAV-CNGB3

Achromatopsia
Phase 2

Milvexian (Factor Xla)

Prevention and Treatment of Thrombosis
Phase 2

JNJ-7100

Diabetic Macular Oedema
Phase 1

AAV-CNGA3

Achromatopsia
Phase 1

JNJ-0237

Chronic Kidney Disease
Phase 1

JNJ-1887​

Macular Degeneration
Phase 1

JNJ-0795

Non-Alcoholic Steatohepatitis
Phase 1

Infectious Diseases and Vaccines, Global Public Health

CABENUVA

HIV Adolescents
Registration

VAC52150

Monovalent Ebola Virus Vaccine
Registration

VAC31518

Janssen COVID-19 Vaccine
Registration

VAC18193

RSV Adult Vaccine
Phase 3

REMICADE (Infliximab)

COVID-19
Phase 3

VAC89220

HIV Px Vaccine
Phase 3

VAC52416

Multivalent ExPEC Vaccine
Phase 3

VAC31518

Janssen COVID-19 Vaccine Pediatrics
Phase 3

JNJ-0953

Influenza
Phase 2

JNJ-3989

Hepatitis B/D Co-infection
Phase 2

JNJ-3989 Combination Therapy

Hepatitis B
Phase 2

JNJ-1802

Dengue Treatment
Phase 2

JNJ-1802

Dengue Prophylaxis
Phase 2

Ultra Long-Acting

HIV
Phase 1

JNJ-7744

Hepatitis B
Phase 1

JNJ-3283 Combination Therapy

Hepatitis B
Phase 1

Immunology

STELARA (ustekinumab)

Pediatric Juvenile Psoriatic Arthritis
Registration

TREMFYA (guselkumab)

Subcutaneous Induction (ASTRO)
Phase 3

TREMFYA (guselkumab)

Crohn's Disease Subcutaneous Induction
Phase 3

TREMFYA (guselkumab)

Psoriatic Arthritis Structural Damage
Phase 3

TREMFYA (guselkumab)

Ulcerative Colitis Monotherapy
Phase 3

TREMFYA (guselkumab)

Pediatric Psoriasis
Phase 3

TREMFYA (guselkumab)

Crohn's Disease
Phase 3

STELARA (ustekinumab)

Pediatric Ulcerative Colitis
Phase 3

STELARA (ustekinumab)

Pediatric Crohn's Disease
Phase 3

SIMPONI (golimumab)

Pediatric Ulcerative Colitis
Phase 3

nipocalimab​

Warm Autoimmune Hemolytic Anemia
Phase 3

TREMFYA (guselkumab)

Giant Cell Arteritis
Phase 2

nipocalimab​

Idiopathic inflammatory myopathy
Phase 2

nipocalimab​

Hemolytic disease of the fetus and newborn
Phase 2

nipocalimab​

Sjogren's Syndrome
Phase 2

nipocalimab​

Systemic lupus erythematosus
Phase 2

​nipocalimab

Rheumatoid Arthritis
Phase 2

JNJ-4804 Combination Therapy

Crohn's Disease
Phase 2

JNJ-4804 Combination Therapy

Psoriatic Arthritis
Phase 2

JNJ-4804 Combination Therapy

Ulcerative Colitis
Phase 2

bermekimab

Hidradenitis Suppurativa
Phase 2

JNJ-2113

Psoriasis
Phase 2

JNJ-9280

Inflammatory Bowel Disease
Phase 1

JNJ-4703

Rheumatoid Arthritis
Phase 1

Neuroscience

seltorexant

Adjunctive treatment for major depressive disorder with insomnia symptoms
Phase 3

nipocalimab​

Generalized Myasthenia Gravis
Phase 3

aticaprant

Adjunctive Major Depressive Disorder
Phase 3

seltorexant

Probable Alzheimer's with clinically significant agitation/aggression
Phase 2

nipocalimab​

Generalized Myasthenia Gravis Pediatrics
Phase 2

SPRAVATO (esketamine)

Major Depressive Disorder with Suicidal Ideation Pediatrics
Phase 2

JNJ-3657

Alzheimer's Disease
Phase 2

JNJ-8942

Bipolar Disease
Phase 2

JNJ-1813

Epilepsy
Phase 2

VAC20121

Alzheimer's Disease
Phase 1

small molecule MGLLi

Psychiatric Disorders
Phase 1

Oncology

niraparib

L1 Prostate cancer metastatic castration-resistant in combination with abiraterone acetate and Prednisone
Registration

IMBRUVICA (ibrutinib)

Pediatric Chronic Graft Versus Host Disease
Registration

IMBRUVICA (ibrutinib)

Frontline Chronic Lymphocytic Leukemia (I + V fixed duration) (GLOW)
Registration

IMBRUVICA (ibrutinib)

Treatment naïve patients with Mantle Cell Lymphoma in combination with Bendamustine and Rituximab (SHINE)
Registration

BALVERSA (erdafitinib)

Urothelial cancer
Registration

teclistamab (BCMA/CD3)

Relapsed refractory multiple myeloma
Registration

niraparib / abiraterone acetate

M1 Metastatic Castration-Sensitive Prostate Cancer in combination with abiraterone acetate and Prednisone
Phase 3

amivantamab / lazertinib

Non Small Cell Lung Cancer
Phase 3

IMBRUVICA (ibrutinib)

Relapsed/refractory patients with Mantle Cell Lymphoma in combination with venetoclax (SYMPATICO)
Phase 3

IMBRUVICA (ibrutinib)

Relapsed/refractory patients with Indolant Non-Hodgkins Lymphoma; (SELENE)
Phase 3

TAR-200 (RIS/gemcitabine plus cetrelimab)

Non-muscle invasive bladder cancer
Phase 3

DARZALEX (daratumumab)

Frontline multiple myeloma transplant eligible (PERSEUS)
Phase 3

DARZALEX (daratumumab)

Frontline multiple myeloma transplant ineligible (CEPHEUS)
Phase 3

DARZALEX (daratumumab)

Smoldering multiple myeloma (SMM3001)
Phase 3

ERLEADA (apalutamide)

High risk prostate cancer (PROTEUS)
Phase 3

ERLEADA (apalutamide)

Localized prostate cancer
Phase 3

CARVYKTI (Ciltacabtagene autoleucel)

Frontline Multiple Myeloma TNI
Phase 3

CARVYKTI (Ciltacabtagene autoleucel)

Relapsed refractory multiple myeloma w/1-3 PL
Phase 3

teclistamab

TE NDMM maintenance (MajesTEC-4)
Phase 3

teclistamab (BCMA/CD3)

Multiple Myeloma 1-3PLs
Phase 3

RYBREVANT (amivantamab)

Subcutaneous (PALOMA-3)
Phase 3

amivantamab / lazertinib

Non Small Cell Lung Cancer 2L
Phase 3

RYBREVANT (amivantamab)

Frontline Non Small Cell Lung Cancer in combination with chemotherapy
Phase 3

TAR-200 (RIS/gemcitabine plus cetrelimab)

Muscle non invasive bladder cancer
Phase 2

BALVERSA (erdafitinib)

Non muscle invasive bladder cancer
Phase 2

BALVERSA (erdafitinib)

Tumor Agnostic
Phase 2

talquetamab (GPRC5D/CD3)

Relapsed refractory multiple myeloma
Phase 2

JNJ-8343

Prostate Cancer
Phase 1

VAC85135

Hematological Malignancies
Phase 1

erdafitinib

Intravesical Delivery System for Localized Bladder Cancer
Phase 1

JNJ-8543

Hematological Malignancies
Phase 1

JNJ-6358

Solid Tumors
Phase 1

JNJ-8780

Hematological Malignancies
Phase 1

JNJ-6617

Hematological Malignancies
Phase 1

JNJ-9414

Prostate Cancer
Phase 1

JNJ-8902

Prostate Cancer
Phase 1

JNJ-6420

Prostate Cancer
Phase 1

JNJ-6633

Hematological Malignancies
Phase 1

JNJ-4681

Hematological Malignancies
Phase 1

JNJ-1330

Colorectal Cancer
Phase 1

Pulmonary Hypertension

UPTRAVI (selexipag)

Pediatric pulmonary arterial hypertension
Phase 3

macitentan

Pulmonary arterial hypertension 75mg
Phase 3

macitentan

Chronic thromboembolic pulmonary hypertension 75mg
Phase 3

OPSUMIT (macitentan)

Pediatric pulmonary arterial hypertension
Phase 3

macitentan w/tadalafil FDC

Pulmonary arterial hypertension
Phase 3

prostacyclin receptor agonist

Pulmonary Arterial Hypertension
Phase 1
  • Phase 1
  • Phase 2
  • Phase 3
  • Registration
This information is accurate as of the date hereof to the best of the Company's knowledge. Johnson & Johnson assumes no obligation to update this information. Strategic Partnerships, Collaborations, and Licensing arrangements - XARELTO: Bayer; milvexian: Bristol Myers Squibb; aprocitentan: Idorsia; X-Linked Retinitis Pigmentosa (AAV-RPGR) and Achromatopsia Gene Therapies (CNGA3 and CNGB3): MeiraGTx; JNJ-7100: Exonate; JNJ-1887: Hemera Biosciences; PNPLA3: Arrowhead Pharmaceuticals; COMPLERA / EVIPLERA, ODEFSEY, SYMTUZA, PREZCOBIX / REZOLSTA FDC: Gilead Sciences; JULUCA and Long acting HIV injectible treatment regimen of rilpivirine and cabotegravir: ViiV Healthcare; COVID-19 vaccine: funded in part with federal funds from the U.S. Department of Health and Human Services; JNJ-3989: Arrowhead Pharmaceuticals; bacteriophage products using recombinant CRISPR/Cas3 Phage platform: Locus Biosciences; Cloudbreak antiviral conjugates (AVCs) including CD388: Cidara Therapeutics; Janssen's HIV vaccine program: IPCAVD, MHRP, HJF, the Ragon Institute, IAVI, Bill & Melinda Gates Foundation, NIAID, U.S. Military HIV Research Program, U.S. Army Medical Materiel Development Activity, MIT, Harvard, HVTN, SAMRC, Bavarian Nordic; Zika vaccine: Beth Israel Deaconess Medical Center (Harvard Medical School); ExPEC: GSK; REMICADE and SIMPONI/SIMPONI ARIA: Schering-Plough (Ireland) Company, a subsidiary of Merck & Co., Inc. and Mitsubishi Tanabe Pharma Corporation; TREMFYA: MorphoSys AG; JNJ-2113, JNJ-4238 and JNJ-5186: Protagonist Therapeutics; Tau Vaccine: AC Immune SA; JNJ-1813: Addex Pharmaceuticals; IMBRUVICA: Pharmacyclics, LLC, an AbbVie company; ZYTIGA: BTG International; VELCADE: Millennium, The Takeda Oncology Company; DARZALEX and DARZALEX FASPRO; Genmab A/S; BALVERSA: Astex Pharmaceuticals; ERLEADA: Regents of California and Memorial Sload Kettering; cilta-cel: Legend Biotech; niraparib: TESARO, an oncology-focused business within GSK; lazertinib: Yuhan Corporation; Duobody Platform bispecific antibody programs: Genmab A/S; ENHANZE platform; Halozyme Therapeutics; XmAb CD28 bispecific antibodies; Xencor; iPSC-derived chimeric antigen receptor (CAR) NK and CAR T-cell product candidates: Fate Therapeutics; UPTRAVI and OPSUMIT: Nippon Shinyaku (co-promotion in Japan); Janssen's Monovalent Ebola Vaccine: Bavarian Nordic A/S, NIAID, IMI2, EFPIA, BARDA, NIH; Filovirus multivalent vaccine: Bavarian Nordic
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