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Selected Pharmaceuticals in Development as of April 19, 2022

Cardiovascular and Metabolism

AAV-CNGA3

Achromatopsia
Phase 1

AAV-CNGB3

Achromatopsia
Phase 2

AAV-RPGR

Retinitis Pigmentosa
Phase 3

aprocitentan

Difficult to treat hypertension
Phase 3

JNJ-0795

Non-Alcoholic Steatohepatitis
Phase 1

JNJ-1887​

Macular Degeneration
Phase 1

JNJ-7100

Diabetic Macular Oedema
Phase 1

Milvexian (Factor Xla)

Prevention and Treatment of Thrombosis
Phase 2

XARELTO (rivaroxaban)

COVID-19 MI (PREVENT-HD)
Phase 3

Infectious Diseases and Vaccines, Global Public Health

CABENUVA

HIV Adolescents
Registration

JNJ-1802

Dengue Treatment
Phase 2

JNJ-1802

Dengue Prophylaxis
Phase 2

JNJ-3989 Combination Therapy

Hepatitis B/D Co-infection
Phase 2

JNJ-3989 Combination Therapy

Hepatitis B
Phase 2

REMICADE (Infliximab)

COVID-19
Phase 3

Ultra Long-Acting

HIV
Phase 1

VAC18193

RSV Adult Vaccine
Phase 3

VAC31518

Janssen COVID-19 Vaccine
Registration

VAC31518

Janssen COVID-19 Vaccine Pediatrics
Phase 3

VAC52150

Monovalent Ebola Virus Vaccine
Registration

VAC52416

Multivalent ExPEC Vaccine
Phase 3

VAC89220

HIV Px Vaccine
Phase 3

Immunology

bermekimab

Hidradenitis Suppurativa
Phase 2

JNJ-2113

Psoriasis
Phase 2

JNJ-4703

Rheumatoid Arthritis
Phase 1

JNJ-4804 Combination Therapy

Psoriatic Arthritis
Phase 2

JNJ-4804 Combination Therapy

Ulcerative Colitis
Phase 2

JNJ-9280

Inflammatory Bowel Disease
Phase 1

nipocalimab​

Warm Autoimmune Hemolytic Anemia
Phase 3

nipocalimab​

Hemolytic disease of the fetus and newborn
Phase 2

nipocalimab​

Sjogren's Syndrome
Phase 2

nipocalimab​

Systemic lupus erythematosus
Phase 2

SIMPONI (golimumab)

Pediatric Ulcerative Colitis
Phase 3

STELARA (ustekinumab)

Pediatric Juvenile Psoriatic Arthritis
Registration

STELARA (ustekinumab)

Pediatric Ulcerative Colitis
Phase 3

STELARA (ustekinumab)

Pediatric Crohn's Disease
Phase 3

TREMFYA (guselkumab)

Crohn's Disease Subcutaneous Induction
Phase 3

TREMFYA (guselkumab)

Psoriatic Arthritis Structural Damage
Phase 3

TREMFYA (guselkumab)

Ulcerative Colitis Monotherapy
Phase 3

TREMFYA (guselkumab)

Pediatric Psoriasis
Phase 3

TREMFYA (guselkumab)

Crohn's Disease
Phase 3

TREMFYA (guselkumab)

Giant Cell Arteritis
Phase 2

​nipocalimab

Rheumatoid Arthritis
Phase 2

Neuroscience

aticaprant

Major Depressive Disorder
Phase 2

JNJ-1813

Epilepsy
Phase 2

JNJ-3657

Alzheimer's Dementia
Phase 2

JNJ-8942

Psychiatric Disorders
Phase 1

nipocalimab​

Myasthenia Gravis
Phase 3

seltorexant

Adjunctive treatment for major depressive disorder with insomnia symptoms
Phase 3

small molecule MGLLi

Psychiatric Disorders
Phase 1

SPRAVATO (esketamine)

Suicidal Ideation Pediatric
Phase 2

VAC20121

Alzheimer's Dementia
Phase 1

Oncology

amivantamab / lazertinib

Non Small Cell Lung Cancer
Phase 3

amivantamab / lazertinib

Non Small Cell Lung Cancer 2L
Phase 3

BALVERSA (erdafitinib)

Urothelial cancer
Registration

BALVERSA (erdafitinib)

Non muscle invasive bladder cancer
Phase 2

BALVERSA (erdafitinib)

Tumor Agnostic
Phase 2

CARVYKTI (Ciltacabtagene autoleucel)

Relapsed refractory multiple myeloma
Registration

CARVYKTI (Ciltacabtagene autoleucel)

Frontline Multiple Myeloma TNI
Phase 3

CARVYKTI (Ciltacabtagene autoleucel)

Relapsed refractory multiple myeloma w/1-3 PL
Phase 3

DARZALEX (daratumumab)

Frontline multiple myeloma transplant eligible (PERSEUS)
Phase 3

DARZALEX (daratumumab)

Frontline multiple myeloma transplant ineligible (CEPHEUS)
Phase 3

DARZALEX (daratumumab)

Smoldering multiple myeloma (SMM3001)
Phase 3

ERLEADA (apalutamide)

High risk prostate cancer (PROTEUS)
Phase 3

ERLEADA (apalutamide)

Localized prostate cancer
Phase 3

IMBRUVICA (ibrutinib)

Pediatric Chronic Graft Versus Host Disease
Registration

IMBRUVICA (ibrutinib)

Frontline Chronic Lymphocytic Leukemia in combination with venetoclax (fixed duration) (GLOW)
Registration

IMBRUVICA (ibrutinib)

Treatment naïve patients with Mantle Cell Lymphoma in combination with Bendamustine and Rituximab (SHINE)
Registration

IMBRUVICA (ibrutinib)

Relapsed/refractory patients with Mantle Cell Lymphoma in combination with venetoclax (SYMPATICO)
Phase 3

IMBRUVICA (ibrutinib)

Relapsed/refractory patients with Indolant Non-Hodgkins Lymphoma; (SELENE)
Phase 3

JNJ-1330

Colorectal Cancer
Phase 1

JNJ-4681

Hematological Malignancies
Phase 1

JNJ-6358

Solid Tumors
Phase 1

JNJ-6420

Prostate Cancer
Phase 1

JNJ-6617

Hematological Malignancies
Phase 1

JNJ-6633

Hematological Malignancies
Phase 1

JNJ-6665

Hematological Malignancies
Phase 1

JNJ-8343

Prostate Cancer
Phase 1

JNJ-8780

Hematological Malignancies
Phase 1

JNJ-8902

Prostate Cancer
Phase 1

JNJ-9414

Prostate Cancer
Phase 1

niraparib

L1 Prostate cancer metastatic castration-resistant in combination with abiraterone acetate and Prednisone
Phase 3

niraparib / abiraterone acetate

M1 Metastatic Castration-Sensitive Prostate Cancer in combination with abiraterone acetate and Prednisone
Phase 3

RYBREVANT (amivantamab)

Frontline Non Small Cell Lung Cancer in combination with chemotherapy
Phase 3

talquetamab (GPRC5D/CD3)

Relapsed refractory multiple myeloma
Phase 2

TAR-200 (RIS/gemcitabine plus cetrelimab)

Non-muscle invasive bladder cancer
Phase 3

TAR-200 (RIS/gemcitabine plus cetrelimab)

Muscle non invasive bladder cancer
Phase 2

teclistamab (BCMA/CD3)

Relapsed refractory multiple myeloma
Registration

teclistamab (BCMA/CD3)

Multiple Myeloma 1-3PLs
Phase 3

Pulmonary Hypertension

macitentan

Pulmonary arterial hypertension 75mg
Phase 3

macitentan

Chronic thromboembolic pulmonary hypertension 75mg
Phase 3

macitentan w/tadalafil FDC

Pulmonary arterial hypertension
Phase 3

OPSUMIT (macitentan)

Pediatric pulmonary arterial hypertension
Phase 3

UPTRAVI (selexipag)

Pediatric pulmonary arterial hypertension
Phase 3
This information is accurate as of the date hereof to the best of the Company's knowledge. Johnson & Johnson assumes no obligation to update this information. Strategic Partnerships, Collaborations, and Licensing arrangements - XARELTO: Bayer; milvexian: Bristol Myers Squibb; aprocitentan: Idorsia; X-Linked Retinitis Pigmentosa (AAV-RPGR) and Achromatopsia Gene Therapies (CNGA3 and CNGB3): MeiraGTx; JNJ-7100: Exonate; JNJ-1887: Hemera Biosciences; PNPLA3: Arrowhead Pharmaceuticals; COMPLERA / EVIPLERA, ODEFSEY, SYMTUZA, PREZCOBIX / REZOLSTA FDC: Gilead Sciences; JULUCA and Long acting HIV injectible treatment regimen of rilpivirine and cabotegravir: ViiV Healthcare; COVID-19 vaccine: funded in part with federal funds from the U.S. Department of Health and Human Services; JNJ-3989: Arrowhead Pharmaceuticals; bacteriophage products using recombinant CRISPR/Cas3 Phage platform: Locus Biosciences; Cloudbreak antiviral conjugates (AVCs) including CD388: Cidara Therapeutics; Janssen's HIV vaccine program: IPCAVD, MHRP, HJF, the Ragon Institute, IAVI, Bill & Melinda Gates Foundation, NIAID, U.S. Military HIV Research Program, U.S. Army Medical Materiel Development Activity, MIT, Harvard, HVTN, SAMRC, Bavarian Nordic; Zika vaccine: Beth Israel Deaconess Medical Center (Harvard Medical School); ExPEC: GSK; REMICADE and SIMPONI/SIMPONI ARIA: Schering-Plough (Ireland) Company, a subsidiary of Merck & Co., Inc. and Mitsubishi Tanabe Pharma Corporation; TREMFYA: MorphoSys AG; JNJ-2113, JNJ-4238 and JNJ-5186: Protagonist Therapeutics; Tau Vaccine: AC Immune SA; JNJ-1813: Addex Pharmaceuticals; IMBRUVICA: Pharmacyclics, LLC, an AbbVie company; ZYTIGA: BTG International; VELCADE: Millennium, The Takeda Oncology Company; DARZALEX and DARZALEX FASPRO; Genmab A/S; BALVERSA: Astex Pharmaceuticals; ERLEADA: Regents of California and Memorial Sload Kettering; cilta-cel: Legend Biotech; niraparib: TESARO, an oncology-focused business within GSK; lazertinib: Yuhan Corporation; Duobody Platform bispecific antibody programs: Genmab A/S; ENHANZE platform; Halozyme Therapeutics; XmAb CD28 bispecific antibodies; Xencor; iPSC-derived chimeric antigen receptor (CAR) NK and CAR T-cell product candidates: Fate Therapeutics; UPTRAVI and OPSUMIT: Nippon Shinyaku (co-promotion in Japan); Janssen's Monovalent Ebola Vaccine: Bavarian Nordic A/S, NIAID, IMI2, EFPIA, BARDA, NIH; Filovirus multivalent vaccine: Bavarian Nordic
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